LNP Trailblazer Kits are designed for quick assembly and assessment of RNA-LNPs in biological systems. Each kit includes a buffer for preparation of RNA cargo and the necessary lipids to form lipid nanoparticles. Once formed, RNA-LNPs are stable in neutral pH buffers for several weeks allowing them to be used serially for repeat experiments. The kit components are compatible with bench top microfluidic mixers and hand mixing by pipette.
Each LNP Trailblazer kit – Pre-mixed contains:
LNP Lipid Mix with your choice of ionizable lipid (selected when ordering)
RNA Dilution Buffer
The LNP Trailblazer kit – Pre-mixed comes with the lipids prepared in solution. General protocols for preparing RNA-LNPs based on a standard eGFP mRNA are included, however optimization for each individual RNA or oligonucleotide should be done by the end user. Also available is a kit with individual lyophilized lipids (K-6300L).
