Sphingosine 1-phosphate (S1P) is a bioactive lysophospholipid formed by phosphorylation of sphingosine by sphingosine kinases. S1P binds to five G-protein coupled receptors designated S1P1-5 leading to cell proliferation, motility, and has a role in regulation cell shape. In addition, S1P acts as an intracellular mediator in a receptor-independent manner regulating cell survival and Ca2+ homeostasis.
1 mg/mL warm acetic acid
0.3 mg/mL MeOH (alternately vortex for 1 min then sonicate in a bath sonicator for 10 minutes until a clear solution is obtained. Heating the solution (50-65°C) can also help with solubilization)
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