PI4-Kinase beta (PI4Kb), active

Product Number: P32-102G

$245.00$353.00

$245.00
$353.00
SKU: P32-102G- Category: Tags: , , ,

PI4-Kinase beta (PI4Kb), active is a full-length, recombinant human PI4KB co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem.

Molecular weight: ~120 kDa
Sequence: Full length
Species: Human
Tag: GST tag
Purity: >90 % (request TDS for lot specific information)
Specific Activity: >30 nmol/min/mg (request TDS for lot specific information)
Expression System: Sf9 insect cells using baculovirus
Genebank Number: BC000029
Applications: PI 4-Kinase assay , western blot.
Formulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Storage and stability: Store product at -70ºC. Stable up to one year.


Product Background

PI4KB is a member of the phosphatidylinositol 4-kinase family (PI4K) and is the first committed step in the production of the second messenger inositol-1,4,5-trisphosphate (PIP3). PI4KB regulates the golgi disintegration/reorganization during mitosis possibly via the phosphorylation of phosphatidylinositol. PI4KB is a type III enzyme that is sensitive to wortmannin and is responsible for regulating the synthesis of agonist-sensitive pools of polyphosphoinositides. PI4KB is critical for glucose-induced insulin secretion due to its capacity to regulate the release of secretory granules. PI4KB inhibits the insulin-stimulated translocation of glucose transporter-4 in mouse adipocytes through its interaction with neuronal calcium sensor.


We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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Antibodies & Proteins

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Enzyme, Kinase, PI4K

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