Purified Anti-PtdIns(3,4)P2 antibody
Applications: ELISA, Immunofluorescence, Protein-Lipid Overlay
Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.
2-8 °C for up to 30 days, -20 °C for greater than 30 days. Do not freeze thaw multiple times.
Featured in Publications
1) Chiang, H. C., L. Wang, et al. (2010). “PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila.” Proc Natl Acad Sci U S A 107(15): 7060-5.