PI(3,4)P2 diC8 (Phosphatidylinositol 3,4-bisphosphate diC8) - Echelon Biosciences

Product Number: P-3408

P-3408

PI(3,4)P2 diC8

PI(3,4)P2 diC8 (Phosphatidylinositol 3,4-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4)P2. [Read More...]

PI(3,4)P2 diC8 (Phosphatidylinositol 3,4-bisphosphate diC8) is a synthetic, purified dioctanoyl PI(3,4)P2.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) is produced in stimulated cells by the action of phosphatidylinositol 3-kinases (PI3Ks) and/or lipid phosphatases (SHIP, TPTE, etc.). PI(3,4)P2 binds the pleckstrin homology (PH)-domain of AKT/PKB leading to cell survival and it also has an important role in podosome formation near focal adhesions.

Categories	Lipids
Filter	diC8, Phosphoinositides, PI(3,4)P2
CAS Number	188885-38-3
Molecular Formula	C25H44Na5O19P3
Molecular Weight (g/mol)	856.48
Purity	>95%
Storage	-20 °C or below
Shipping Temp	Dry ice or gel ice depending on destination

Technical Data Sheet

1. Elge, S., C. Brearley, et al. (2001). “An Arabidopsis inositol phospholipid kinase strongly expressed in procambial cells: synthesis of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 in insect cells by 5-phosphorylation of precursors.” Plant J 26(6): 561-71.
2. Tong, Q., N. Gamper, et al. (2004). “Direct activation of the epithelial Na(+) channel by phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,4-bisphosphate produced by phosphoinositide 3-OH kinase.” J Biol Chem 279(21): 22654-63.
3. Shen, J., et al. (2009). “Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasis.” Nat Cell Biol 11(6): 769-776.
4. Lopez, S. M., et al. (2013). “Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.” Biochem Biophys Res Commun 440(2): 277-282.
5. Choi, S., et al. (2019). “A nuclear phosphoinositide kinase complex regulates p53.” Nature cell biology 21: 462-475.

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