ALC-0159

Product Number: N-2010

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ALC-0159 is a PEGylated lipid which has been used to form lipid nanoparticles for delivery of RNA. ALC-0159 is one of the components in the BNT162b2 vaccine against SARS-CoV-2 in addition to ALC-0315, DSPC, and cholesterol. A small amount of a PEG derivatized lipid like ALC-0159 [0.5-3%] is incorporated into LNPs to increase the circulatory half-life in the body. This is a reagent grade product, for research use only.

References
1) R. Tenchov, R. Bird, A. E. Curtze, Q. Zhou (2021) “Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement” ACS Nano, DOI: 10.1021/acsnano.1c04996.
2) K.H. Moss, P. Popova, et al. (2019) “Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides” Mol. Pharmaceutics 16, 2265–2277, DOI: 10.1021/acs.molpharmaceut.8b01290.
3) Y. Duan, A. Dhar, et al. (2020) “A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems” RSC Adv.,10, 26777-26791.

CAS Number

1849616-42-7

Molecular Formula

(C2H4O)nC31H63NO2

Molecular Weight (g/mol)

~2330

Purity

>95%

Storage

-20 °C or below

Categories

Lipids

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Ionizable/Cationic Lipids

Shipping Temp

Ambient Temperature

Technical Data Sheet

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