ALC-0159 is a PEGylated lipid which has been used to form lipid nanoparticles for delivery of RNA. ALC-0159 is one of the components in the BNT162b2 vaccine against SARS-CoV-2 in addition to ALC-0315, DSPC, and cholesterol. This product is for research use only and not for human use.
1) R. Tenchov, R. Bird, A. E. Curtze, Q. Zhou (2021) “Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement” ACS Nano, DOI: 10.1021/acsnano.1c04996.
2) K.H. Moss, P. Popova, et al. (2019) “Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides” Mol. Pharmaceutics 16, 2265–2277, DOI: 10.1021/acs.molpharmaceut.8b01290.
3) Y. Duan, A. Dhar, et al. (2020) “A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems” RSC Adv.,10, 26777-26791.