BODIPY FL Phosphatidylinositol is a water soluble analog of Phosphatidylinositol (PI) labeled with the green fluorophore, Bodipy®-FL at the sn-1 position.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.
1) Caromile, L. A., A. Oganesian, et al. (2010). “The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.” J Biol Chem 285(14): 10487-96.
2) Otieno, A. C., E. W. Quainoo, et al. (2008). “Metal cations for the determination of fluorescent phosphoinositides by capillary electrophoresis.” J Sep Sci 31(22): 3894-901.
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