PI(3,4,5)P3 diC16 (Phosphatidylinositol 3,4,5-trisphosphate diC16) ammonium salt is a synthetic, purified dipalmitoyl PI(3,4,5)P3.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.
Featured in Publications
AJP – Renal Physiology, Apr 2006
AJP – Lung Cellular and Molecular Physiol, Mar 2006
Product Keywords: Dipalmitoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 C16, PI(3,4,5)P3 C16, or PIP3
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