Stigmasterol is among the most abundant sterols found in plants. Structurally similar to cholesterol, it helps maintain cell membrane integrity in plants. It has been studied for its cholesterol-lowering, anti-inflammatory, and antioxidant properties in humans. It serves as a precursor in the synthesis of hormones like progesterone and has shown potential in supporting cardiovascular and joint health. Substituting sterols for cholesterol in lipid nanoparticle (LNP) formulations can influence morphology, internal structure, and endosomal escape. These analogs can result in substantial increases in gene delivery via LNPs.
