Geranylgeranyl Diphosphate (GGPP)

Product Number: I-0200

Geranylgeranyl Diphosphate (GGPP) - Echelon Biosciences

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Geranylgeranyl diphosphate (GGPP) is an intermediate in isoprenoid biosynthesis. Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. GGPP is formed by the addition of IPP to farnesyl diphosphate catalyzed by geranylgeranyl diphosphate synthase.

Provided as the tris-ammonium salt

Product Keywords: Geranylgeranyl pyrophosphate, GGPP

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Categories	Biochemical Reagents
Filter	Isoprenoid, Isoprenoid Diphosphate
CAS Number	104715-21-1
Molecular Formula	C20H45N3O7P2
Molecular Weight (g/mol)	501.53
Purity	>95%
Storage	-20 °C or below

Technical Data Sheet

1. Gibot, L., J. Follet, et al. (2009). “Human caspase 7 is positively controlled by SREBP-1 and SREBP-2.” Biochem J 420(3): 473-83.
2. Lai, D., B. Lluncor, et al. (2009). “Reconstruction of the archaeal isoprenoid ether lipid biosynthesis pathway in Escherichia coli through digeranylgeranylglyceryl phosphate.” Metabolic Engineering 11(3): 184.
3. Zhou, X.-P., K.-Y. Wu, et al. (2008). “TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis.” Proceedings of the National Academy of Sciences 105(44): 17181-17186.
4. Gruenbacher, G., H. Gander, et al. (2010). “IL-2 costimulation enables statin-mediated activation of human NK cells, preferentially through a mechanism involving CD56+ dendritic cells.” Cancer Res 70(23): 9611-20.
5. Gruenbacher, G., et al. (2016). “Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens.” Cell Reports 16(2): 444-456.
6. Sugimoto, H., et al. (2017). “Bioanalysis of farnesyl pyrophosphate in human plasma by high-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry and hybrid quadrupole Orbitrap high-resolution mass spectrometry.” Anal Bioanal Chem 409(14): 3551-3560.

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