Isopentenyl Diphosphate (IPP)

Product Number: I-0050


Isopentenyl diphosphate (IPP) is a building block in the isoprenoid biosynthesis pathway. Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway.

Provided as the tris-ammonium salt

Alternate Names: Isopentenyl pyrophosphate, IPP

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Biochemical Reagents


Isoprenoid, Isoprenoid Diphosphate

CAS Number


Molecular Formula


Molecular Weight (g/mol)





-20 °C or below

Shipping Temp

Gel Ice

Technical Data Sheet

1. Wouters, J., Y. Oudjama, et al. (2003). “Structure and mechanism of action of isopentenylpyrophosphate- dimethylallylpyrophosphate isomerase.” J Am Chem Soc 125(11): 3198-9.
2. Schilmiller, A. L., I. Schauvinhold, et al. (2009). “Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate.” Proceedings of the National Academy of Sciences 106(26): 10865-10870.
3. Bang, S., S. Yoo, et al. (2010). “Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3.” J Biol Chem 285(25): 19362-71.
4. Haymond, A., et al. (2014). “Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase).” PLoS ONE 9(8): e106243.
5. Wang, X., et al. (2018). “MEPicides: α,β-Unsaturated Fosmidomycin Analogs as DXR inhibitors against Malaria.” J Med Chem 61(19): 8847-8858.
6. Rea, K. A., et al. (2019). “Biosynthesis of cannflavins A and B from Cannabis sativa L.” Phytochemistry 164: 162-171.

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