CYM50308 is a potent and selective S1P4 receptor agonist with EC50 of 37.7 nM – 79.1nM. It is inactive against the S1P1, S1P2, and S1P3 receptors up to 25 μM, and the S1P5 receptor up to 2.1 μM.
References
1) Urbano et al. Discovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2- (alkylimino)thiazolidin-4-one chemotype, Bioorganic & Medicinal Chemistry Letters, 2011, 6739-6745.
2) Guerrero et al. Identification of a novel agonist of the sphingosine 1-phosphate receptor 4 (S1P4), Probe Reports from the NIH Molecular Libraries Program. http://www.ncbi.nlm.nih.gov/books/NBK143556/
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