Dimethylallyl Diphosphate (DMAPP)

Product Number: I-0051

Dimethylallyl Diphosphate (DMAPP) - Echelon Biosciences

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Dimethylallyl diphosphate (DMAPP) is a building block in the isoprenoid biosynthesis pathway. Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway.

Provided as the tris-ammonium salt

Alternate Names: Dimethylallyl pyrophosphate, DMPP

Bulk discounts available, please email echelon@echelon-inc.com for information.

Categories	Biochemical Reagents
Filter	Isoprenoid, Isoprenoid Diphosphate
CAS Number	1186-30-7
Molecular Formula	C5H21N3O7P2
Molecular Weight (g/mol)	297.18
Purity	>95%
Storage	-20 °C or below

Technical Data Sheet

1. Burke, C. and R. Croteau (2002). “Interaction with the small subunit of geranyl diphosphate synthase modifies the chain length specificity of geranylgeranyl diphosphate synthase to produce geranyl diphosphate.” J Biol Chem 277(5): 3141-9.
2. Poliquin, K., Y. V. Ershov, et al. (2004). “Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro.” J Bacteriol 186(14): 4685-4693.
3. Schilmiller, A. L., I. Schauvinhold, et al. (2009). “Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate.” Proceedings of the National Academy of Sciences 106(26): 10865-10870.
4. Haymond, A., et al. (2014). “Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase).” PLoS ONE 9(8): e106243.
5. Gruenbacher, G., et al. (2016). “Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens.” Cell Reports 16(2): 444-456.
6. Ma, Y., et al. (2019). “Metabolic Engineering of the MEP Pathway in Bacillus subtilis for Increased Biosynthesis of Menaquinone-7.” ACS Synthetic Biology 8(7): 1620-1630.

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