1-Deoxy-D-xylulose 5-phosphate (DXP)

Isoprenoid compounds are a diverse group of natural products which are essential components in all cells. Isoprenoids are biosynthesized from the simple precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Eukaryotes, fungi, and some gram-positive bacteria produce IPP through the mevalonate (MVA) pathway whereas gram-negative and some gram-positive bacteria utilize the non-mevalonate or 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. 1-Deoxy-D-xylulose 5-phosphate (DXP) is an intermediate in the non-mevalonate pathway and is formed from pyruvate and glyceraldehyde 3-phosphate by DXP synthase. It is converted to MEP by MEP Synthase (DXP reductoisomerase).

Provided as the sodium salt

Alternate Names: 1-Deoxy-D-xylulose 5-phosphate, 1-Deoxyxylulose 5-phosphate, Deoxyxylulose phosphate, DOXP, DXP

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Publications

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1) Poliquin, K., Y. V. Ershov, et al. (2004). “Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro.” J Bacteriol 186(14): 4685-4693.
2) Gottlin, E. B., R. E. Benson, et al. (2003). “High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.” J Biomol Screen 8(3): 332-9.
3) Bailey, A. M., S. Mahapatra, et al. (2002). “Identification, cloning, purification, and enzymatic characterization of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate synthase.” Glycobiology 12(12): 813-20.
4) Zhou, K., et al. (2012). “Metabolite Profiling Identified Methylerythritol Cyclodiphosphate Efflux as a Limiting Step in Microbial Isoprenoid Production.” PLoS ONE 7(11): e47513.
5) Haymond, A., et al. (2014). “Kinetic Characterization and Allosteric Inhibition of the Yersinia pestis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (MEP Synthase).” PLoS ONE 9(8): e106243.
6) Parkinson, E. I., et al. (2019). “Fosmidomycin biosynthesis diverges from related phosphonate natural products.” Nat Chem Biol 15: 1049-1056.