1R,2R-B13 (Ceramidase inhibitor)

Product Number: B-0042

$78.00$269.00

$78.00
$132.00
$269.00

Ceramides are bioactive sphingolipids which induce apoptosis in cells. Ceramidases, which hydrolyze the fatty acid chain, keep ceramide levels in check and have been proposed as a target for small-molecule inhibitors for anti-cancer therapy. B13 (or D-NMAPPD) is a potent ceramidase inhibitor which causes aopotosis in a number of cell lines including colorectal, HL60, melanoma, and keratinocyes.

References

1) A. Bielawska, C.M. Linardic, Y. Hannun “Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs” J. Biol. Chem., 1992, 267, 18493-7.
2) M. Raisova, G. Goltz, et al. “Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes” FEBS Letters 2002, 516, 47-52.
3) Bhabak, Krishna P.; Kleuser, Burkhard “Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues” Bioorganic & Medicinal Chemistry 2013, 21, 874-882.

Categories

Biochemical Reagents

Filter

Inhibitor, Sphingolipid

CAS Number

35922-06-6

Molecular Formula

C23H38N2O5

Molecular Weight (g/mol)

422.56

Purity

>95%

Storage

-20 °C or below

Technical Data Sheet

You may also like…

Scroll to Top