Des-1 Inhibitor

Catalog No.:  B-0027
MW: 329.74
CAS: 1847471-67-3

SKI-II is a commonly used inhibitor of both sphingosine kinase I (SPHK1) and 2 (SPHK2). Recently it has been shown to inhibit dihydroceramide desaturase (Des1) which Aurelio et al. suggest is actually responsible for its anti-proliferative activity, not SPHK inhibition. Compound 34 is an analog of SKI-II and is a selective Des1 inhibitor which shows no activity against either SPHK1 or SPHK2. 34 inhibits PC3 cell growth (GIC50 = 0.34 μM) but some of this may be due to inhibition of another target


L. Aurelio, C.V. Scullino, et al.. “From Sphingosine Kinase to Dihydroceramide desaturase: A Structure?Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)” J. Med. Chem., 59, 965-984, DOI: 10.1021/acs.jmedchem.5b01439.

Related Products
Sphingolipid Pathway Inhibitors
Sphingosine Kinase Activity Assay (K-3500)
Sphingosine 1-Phosphate ELISA (K-1900)
Sphingosine Kinase 1 (E-K068) & 2 (E-K069)

Options/Sizes Pricing
B-0027-10mg $ 79.00
B-0027-50mg $ 310.00
Additional Information:
Tech Data Sheet - B-0027

Add a specific quantity to your cart    *  

Back to the webstore startpage      Back to the product overview      Your Shopping Cart      Terms of Service

assay and reagents for drug discovery in lipid signaling pathways