Phosphatidylinositol 3,4,5-trisphosphate diC16 (PI(3,4,5)P3 diC16)

Catalog No.:  P-3916
MW: 1204.84
CAS: 165689-82-7

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.


-20 °C

Featured in Publications:

1) Weiner, O. D., P. O. Neilsen, et al. (2002). "A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity." Nat Cell Biol 4(7): 509-13.
2) Merlot, S., R. Meili, et al. (2003). "A PTEN-related 5-phosphatidylinositol phosphatase localized in the Golgi." J Biol Chem 278(41): 39866-73.
3) Shenker, B. J., M. Dlakic, et al. (2007). "A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity." J Immunol 178(8): 5099-108.
4) Horikoshi, Y., S. Hamada, et al. (2011). "Phosphoinositide binding by par-3 involved in par-3 localization." Cell Struct Funct 36(1): 97-102.

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Product Keywords: Dipalmitoyl Phosphatidylinositol 3,4,5-trisphosphate, PtdIns(3,4,5)P3 C16, PI(3,4,5)P3 C16, or PIP3

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Options/Sizes Pricing
P-3916-100ug $ 39.00
P-3916-500ug $ 175.00
P-3916-1mg $ 311.00
Additional Information:
Tech Data Sheet - TDS_ P-3916 _Rev 6

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assay and reagents for drug discovery in lipid signaling pathways