Phosphatidylinositol 3,5-bisphosphate diC8 (PI(3,5)P2 diC8)

Catalog No.:  P-3508
MW: 856.48
CAS: 299216-96-6

Description:  Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,5-bisphosphate is in very low abundance and is required for retrograde membrane trafficking from lysosomal and late endosomal compartments to the Golgi and is involved in autophagy. PI(3,5)P2 levels are controlled by the 5-kinase PIKfyve and the 5-phosphatase Fig4/Sac3 and disregulation is linked to several human neuropathies (eg Chacot-Marie-Tooth disease).



Featured in Publications:

1) Marcus, S. L., M. R. Wenk, et al. (2001). "A synaptojanin-homologous region of Salmonella typhimurium SigD is essential for inositol phosphatase activity and Akt activation." FEBS Lett 494(3): 201-7
2) Johnson, L. M., K. M. James, et al. (2005). "Identification of Key Residues in the A-Raf Kinase Important for Phosphoinositide Lipid Binding Specificity." Biochemistry 44(9): 3432-3440.
3) Ikonomov, O. C., D. Sbrissa, et al. (2009). "Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes." J Biol Chem 284(36): 23961-71.

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Product Keywords: Dioctanoyl Phosphatidylinositol 3,5-bisphosphate, PtdIns(3,5)P2 C8, PI(3,5)P2 C8

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Options/Sizes Pricing
P-3508-100ug $ 49.00
P-3508-500ug $ 229.00
P-3508-1mg $ 410.00
Additional Information:

Tech Data Sheet - TDS_P-3504, P-3508, P-3516_ Rev 7

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assay and reagents for drug discovery in lipid signaling pathways