Biotin Phosphatidylinositol 3,4,5-trisphosphate

Catalog No.:  C-39B6
MW: 1278.78

Description:  Water soluble analog of PI(3,4,5)P2 (PIP3) labeled with biotin at the sn-1 position.

Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.


  • -20 °C

Featured in Publications:

1) Anzelon, A. N., H. Wu, et al. (2003). "Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function." Nat Immunol 4(3): 287-94.

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Options/Sizes Pricing
C-39B6-10ug $ 140.00
C-39B6-50ug $ 592.00
Additional Information:
Tech Data Sheet - C-39B6

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assay and reagents for drug discovery in lipid signaling pathways