YSK05

Product No: N-1050

$100
$210
$578

YSK05 is an ionizable lipid which is used to make lipid nanoparticles for delivery of siRNA. YSK05 LNPs delivered siRNA to hepatocytes and demonstrated gene silencing after intravenous administration.

Categories

Lipids

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Ionizable/Cationic Lipids

CAS Number

1318793-78-0

Molecular Formula

C42H77NO2

Molecular Weight (g/mol)

628.08

Purity

>95%

Storage

-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

1) Sato, Y., Hatakeyama, H., Sakurai, Y., et al. (2012) “A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo.” J. Control. Release 163(3), 267-276.
2) Sato, Y., Hatakeyama, H., Kohara, M. (2016) “A Multifunctional Envelope-Type Nano Device Containing a pH-Sensitive Cationic Lipid for Efficient Delivery of Short Interfering RNA to Hepatocytes In Vivo” Methods Mol. Bio. 1364:71-8. doi: 10.1007/978-1-4939-3112-5_7.
3) Shobaki, N., Sato, Y., Hatakeyama, H. (2018) “Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting” Int. J. Nanomedicine 13: 8395–8410, doi: 10.2147/IJN.S188016.

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