YSK05 is an ionizable lipid which is used to make lipid nanoparticles for delivery of siRNA. YSK05 LNPs delivered siRNA to hepatocytes and demonstrated gene silencing after intravenous administration.
| Categories | Lipids |
|---|---|
| Filter | Ionizable/Cationic Lipids |
| CAS Number | 1318793-78-0 |
| Molecular Formula | C42H77NO2 |
| Molecular Weight (g/mol) | 628.08 |
| Purity | >95% |
| Storage | -20 °C or below |
1) Sato, Y., Hatakeyama, H., Sakurai, Y., et al. (2012) “A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo.” J. Control. Release 163(3), 267-276.
2) Sato, Y., Hatakeyama, H., Kohara, M. (2016) “A Multifunctional Envelope-Type Nano Device Containing a pH-Sensitive Cationic Lipid for Efficient Delivery of Short Interfering RNA to Hepatocytes In Vivo” Methods Mol. Bio. 1364:71-8. doi: 10.1007/978-1-4939-3112-5_7.
3) Shobaki, N., Sato, Y., Hatakeyama, H. (2018) “Mixing lipids to manipulate the ionization status of lipid nanoparticles for specific tissue targeting” Int. J. Nanomedicine 13: 8395–8410, doi: 10.2147/IJN.S188016.
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