VO-OHpic (PTEN Inhibitor)

Product Number: B-0351


The vanadium complex VO-OHpic is a potent, reversible, allosteric inhibitor of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) which hydrolyzes the 3-phosphate from phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3, formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. VO-OHpic is reported to be selective for PTEN (IC50~35 nM) compared with other cysteine-based phosphatases (PTPβ, SAC, MTM, & SopB, IC50>4 μM). Treatment of insulin-stimulated NIH 3T3 and L1 fibroblasts caused an increase in Akt-phosphorylation indicating inhibition of PTEN in vivo.



Biochemical Reagents


Inhibitor, PI3K, PTEN

CAS Number


Molecular Formula

C12H10N2O8V + 3H2O

Molecular Weight (g/mol)



-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

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