ARN14988 (aCDase Inhibitor)

Product Number: B-0041


Acid ceramidase (aCDase) is a lysosomal amidase which hydrolyzes the acyl chain from ceramides forming sphingosine which is subsequently phosphorylated to the bioactive lipid sphingosine 1-phosphate. aCDase is upregulated in many cancer types such as melanoma, prostate, head, neck, and colon cancers. ARN14988 is a potent inhibitor of aCDase in vitro (IC50 = 12 nM) and in A375 melanoma cells (IC50 = 1.5uM). ARN14988 is weakly cytotoxic by itself, but shows a synergystic effect with some common anti-cancer drugs (5-Fluorouracil, vemurafinib, and taxol) in proliferative G361 cells.


Biochemical Reagents


Inhibitor, Sphingolipid

CAS Number


Molecular Formula


Molecular Weight (g/mol)





-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

N. Realini, et al. “Acid Ceramidase in Melanoma: expression, localization, and effects of pharmacological inhibition” J. Biol. Chem., 2016, 291, 2422-2434.

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