GRI977143 (LPA2 Agonist)

Product Number: B-0070

$186.00$710.00

$186.00
$710.00
SKU: B-0070- Category: Tags: , , , ,

LPA is a growth factor-like mediator and a ligand for multiple GPCR. The LPA2 GPCR mediates antiapoptotic and mucosal barrier-protective effectes in the gut. LPA GPCR activate antiapoptotic kinase pathways, inhibit aopotosis, promote cell regeneration, and augment DNA repair. GRI977143 can be used for the attenuation of programmed cell death elicited by radiation and chemotherapeutic agents, and also shows strong radioprotective action by rescuing cells from apoptosis and mice irradiated with lethal doses of γ-irradiation.

Storage

-20 °C or below

References

1) R. Patil, et al “Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor” Journal of Medicinal Chemistry, 2014, 57, 7136-7140
2) G.N. Kiss, et al. “Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions” Mol. Pharmacol. 2012, 82, 1162-1173


Documents

Technical Data Sheet

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

Categories

Biochemical Reagents

Filter

Agonist, Lysophosphatidic Acid

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