GRI977143 (LPA2 Agonist)

Product Number: B-0070


SKU: B-0070- Category: Tags: , , , ,

LPA is a growth factor-like mediator and a ligand for multiple GPCR. The LPA2 GPCR mediates antiapoptotic and mucosal barrier-protective effectes in the gut. LPA GPCR activate antiapoptotic kinase pathways, inhibit aopotosis, promote cell regeneration, and augment DNA repair. GRI977143 can be used for the attenuation of programmed cell death elicited by radiation and chemotherapeutic agents, and also shows strong radioprotective action by rescuing cells from apoptosis and mice irradiated with lethal doses of γ-irradiation.


-20 °C or below


1) R. Patil, et al “Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor” Journal of Medicinal Chemistry, 2014, 57, 7136-7140
2) G.N. Kiss, et al. “Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions” Mol. Pharmacol. 2012, 82, 1162-1173


Technical Data Sheet

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at



Biochemical Reagents


Agonist, Lysophosphatidic Acid

You may also like…

  • BrP-LPA (LPA bromophosphonate) - Echelon Biosciences
    Biochemical Reagents


    Product Number: L-7416

    $145.00$652.00 View products
  • Kits & Assays

    Lysophosphatidic Acid ELISA Kit

    Product Number: K-2800S

    $923.00 View products
  • Oleoyl LPA, 18:1 LPA - Echelon Biosciences

    Oleoyl LPA, 18:1 LPA

    Product Number: L-0181

    $19.00$152.00 View products
  • Antibodies & Proteins

    Autotaxin Enzyme, active

    Product Number: E-4000

    $96.00$454.00 View products
Shopping Cart
Scroll to Top