Thio-ccPA

Product Number: L-7118

$126$217

$126
$217
SKU: L-7118 Category: Tags: , , ,

Thio-ccPA is a stabilized analogue of carbacyclic phosphatidic acid (ccPA). It inhibits the lysoPLD activity of Autotaxin (ATX) and acts as an LPA1/3 receptor antagonist. Thio-ccPA decreases the viability of B16F10, A375, and MeWo melanoma cell lines. Addition of endogenous LPA did not reverse these effects in B16F10 cells. Thio-ccPA decreased the number of pulmonary and non-pulmonary metastases in a B16F10 metastatic melanoma mouse model.

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Lipids

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Lysophospholipid

CAS Number

779333-56-1

Molecular Formula

C22H40NaO4PS

Molecular Weight (g/mol)

454.6

Purity

>95%

Storage

-20 °C or below

Technical Data Sheet

1) Xu, Y., G. Jiang, et al. (2006). “Phosphonothioate and Fluoromethylene Phosphonate Analogues of Cyclic Phosphatidic Acid: Novel Antagonists of Lysophosphatidic Acid Receptors.” Journal of Medicinal Chemistry 49(17): 5309.
2) Altman, M. K., V. Gopal, et al. (2010). “Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.” Mol Cancer 9: 140.

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