Spantide II

Product Number: 712-36

$158.00

$158.00

CAS Number: 129176-97-2
Molecular Weight: 1667.7
Salt Form: TFA
Purity: >96%
Sequence (3-letter): e-nicotinoyl-D-Lys-Pro-3Pal-Pro-(3,4Cl)D-Phe-Asn-D-Trp-Phe-D-Trp-Leu-Nle-NH2 (3Pal = 3-pyridylalanine)
Sequence (1-letter): (e-nicotinoyl)kP(3Pal)P((3,4Cl)D)FNwFwL(Nle)-NH2
Storage: -20 °C or below
Solubility: water (1 mg/mL)

Spantide II is an undecapeptide substance P (SP) analog that is more potent as a substance P antagonist than spantide I and less effective in releasing histamine from mast cells. It is a neurokinin-1 receptor (NK-1R) antagonist that is used to control inflammation, particularly in skin conditions, and has negligible neurotoxicity.

References

1. Hakanson, R. et al. (1990) “Spantide II, a novel tachykinin antagonist having high potency and low histamine-releasing effect” Regul. Pept. 31 (1): 75-82.
2.Kincy-Cain, T. and Bost, K.L. (1996) “Increased susceptibility of mice to Salmonella infection following in vivo treatment with the substance P antagonist, spantide II” J. Immunol. 157 (1): 255-264.
3. Gerfen, C.R. (1991) “Substance P (neurokinin-1) receptor mRNA is selectively expressed in cholinergic neurons in the striatum and basal forebrain” Brain Res. 556 (1): 165–170.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

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