CAS Number: 96426-21-0
Molecular Weight: 490.21
Salt Form: TFA
Sequence (3-letter): Gly-Arg-Gly-Asp-Ser-OH
Sequence (1-letter): GRGDS-OH
Storage: -20 °C or below
Solubility: water or 5% acetic acid
GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin. Osteopontin uses this motif for cell adhesion. This peptide includes the RGD (Arg-Gly-Asp) sequence found in many extracellular matrix adhesive proteins. GRGDS is a synthetic antagonist of integrin function and competitively inhibits direct fibroblast binding to fibronectin.
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2. Denhardt, D.T. and Guo, X. (1993) “Osteopontin: a protein with diverse functions” FASEB J. 7: 1475-1482.