CAS Number: 96426-21-0
Molecular Weight: 490.21
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Gly-Arg-Gly-Asp-Ser-OH
Sequence (1-letter): GRGDS-OH
Storage: -20 °C or below
Solubility: water or 5% acetic acid
GRGDS is a cell binding protein domain derived from the cell-binding region of fibronectin. Osteopontin uses this motif for cell adhesion. This peptide includes the RGD (Arg-Gly-Asp) sequence found in many extracellular matrix adhesive proteins. GRGDS is a synthetic antagonist of integrin function and competitively inhibits direct fibroblast binding to fibronectin.
References
1.Miyamoto, S., Akiyama, S.A. and Yamada, K.M. (1995) “Synergistic Roles for Receptor Occupancy and Aggregation in Integrin Transmembrane Function” Science 267 (5199): 883-885.
2. Denhardt, D.T. and Guo, X. (1993) “Osteopontin: a protein with diverse functions” FASEB J. 7: 1475-1482.
