Endothelin 3, cyclic (human, mouse, rabbit, rat)

Product Number: 335-10



CAS Number: 117399-93-6
Molecular Weight: 2645.16
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Cys-Thr-Cys-Phe-Thr-Tyr-Lys-Asp-Lys-Glu-Cys-Val-Tyr-Tyr-Cys-His-Leu-Asp-Ile-Ile-Trp-OH (Cys1-Cys15, Cys3-Cys11)
Storage: -20 °C or below
Solubility: water >1 mg/mL

Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. Endothelin-3 is an endogenous neuropeptide and potent vasoconstrictor. Endothelin-3 has been reported to attenuate thrombin-evoked aggregation of human platelets, acts as a potent stimulator of interleukin-6 production by endothelial cell lines, activates phospholipase C in fibroblasts expressing ETA receptors and induces the production of VEGF.


1. Baynash, A.G. (1994) “Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons” Cell 79 (7): 1277–1285.
2. Matsumoto, H. et al. (1989) “Abundance of endothelin-3 in rat intestine, pituitary gland and brain” 164 (1): 74-80.
3. Sakamoto, A. et al. (1991) “Cloning and functional expression of human cDNA for the ETB endothelin receptor” Biochem. Biophys. Res. Commun. 178 (2): 656–663

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Cardiovascular, Neuropeptides & Hormones

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