Phosphatidylinositol 5-phosphate diC8 (PI(5)P diC8) is a synthetic, purified dioctanoyl PI(5)P.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 5-phosphate (PI(5)P) is a rare lipid found in the nucleus that can bind the PHD finger of the nuclear adapter protein ING2. PI(5)P is phosphorylated to PI(4,5)P2 by Type II PIP kinases.
Alternate Names: Dioctanoyl Phosphatidylinositol 5-phosphate, PtdIns(5)P C8, PI(5)P C8, or PI5P
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2) Hinchliffe, K. A., M. L. Giudici, et al. (2002). “Type IIalpha phosphatidylinositol phosphate kinase associates with the plasma membrane via interaction with type I isoforms.” Biochem J 363(Pt 3): 563-70.
3) Sbrissa, D., O. C. Ikonomov, et al. (2002). “Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells.” J Biol Chem 277(49): 47276-84.