PI4-Kinase II alpha (PI4KIIa), active

Product Number: P21-10G


SKU: P21-10G- Category: Tags: , , ,

Full-length recombinant human PI4KIIA was co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Enzyme obtained from SignalChem.

Molecular weight: ~79 kDa
Sequence: Full length
Species: Human
Tag: GST tag
Purity: >90 % (request TDS for lot specific information)
Specific Activity: >30 nmol/min/mg (request TDS for lot specific information)
Expression System: Sf9 insect cells using baculovirus
Genebank Number: NM_018425
Applications: PI 4-Kinase assay, western blot.
Formulation: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Storage and stability: Store product at -70ºC. Stable up to one year.

Product Description

PI4KIIA or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KIIA phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4KIIA is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4KIIA generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes. PI4KIIA is also required for Wnt to regulate LRP6 phosphorylation.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com



Antibodies & Proteins


Enzyme, Kinase, PI4K

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