1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-stearoyl (N-stearoyl-DPPE) is a type of N-acylphosphatidylethanolamine (NAPE) and an important intermediate in the endocannabinoid biosynthesis pathway. Fatty acid amides are formed by hydrolysis of NAPEs by a specific phospholiase D (NAPE-PLD), and metabolized by fatty acid amide hydrolases (FAAH). Both of these enzymes are emerging drug targets initially for the treatment of inflammatory pain and ischemia. Specifically, N-stearoyl-ethanolamine (SEA) is known for its in vivo anti-inflammatory properties including suppression of allergic dermatitis; and could be the mediator preventing obesity in C57BL/6J mice fed a high fat diet.
| Categories | Lipids |
|---|---|
| Filter | Phosphatidylethanolamine |
| Molecular Formula | C55H111N2O9P |
| Molecular Weight (g/mol) | 975.47 |
| CAS Number | 113701-56-7 |
| Storage | -20 °C or below |
1) Dalle Carbonare M, et al (2008) A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story. J Neuroendocrinol, 20 Suppl 1:26-34 PMID: 18426496
2) Dosoky NS, Guo L, Chen Z, Feigley AV, Davies SS. (2018) Dietary Fatty Acids Control the Species of N-Acyl-Phosphatidylethanolamines Synthesized by Therapeutically Modified Bacteria in the Intestinal Tract. ACS Infect Dis 4(1):3-13. PMID: 29019649
