N-Stearoyl-DPPE

L-2418

$50.00$316.00

$50.00
$87.00
$316.00

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-stearoyl (N-stearoyl-DPPE) is a type of N-acylphosphatidylethanolamine (NAPE) and an important intermediate in the endocannabinoid biosynthesis pathway. Fatty acid amides are formed by hydrolysis of NAPEs by a specific phospholiase D (NAPE-PLD), and metabolized by fatty acid amide hydrolases (FAAH).  Both of these enzymes are emerging drug targets initially for the treatment of inflammatory pain and ischemia. Specifically, N-stearoyl-ethanolamine (SEA) is known for its in vivo anti-inflammatory properties including suppression of allergic dermatitis; and could be the mediator preventing obesity in C57BL/6J mice fed a high fat diet.

References

  1. Dalle Carbonare M, et al (2008) A saturated N-acylethanolamine other than N-palmitoyl ethanolamine with anti-inflammatory properties: a neglected story. J Neuroendocrinol, 20 Suppl 1:26-34 PMID: 18426496
  2. Dosoky NS, Guo L, Chen Z, Feigley AV, Davies SS. (2018) Dietary Fatty Acids Control the Species of N-Acyl-Phosphatidylethanolamines Synthesized by Therapeutically Modified Bacteria in the Intestinal Tract. ACS Infect Dis 4(1):3-13. PMID: 29019649

Documents

Technical Data Sheet

 

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com

 

Categories

Lipids

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Phosphatidylethanolamine

Molecular Formula

C55H111N2O9P

Molecular Weight (g/mol)

975.47

CAS Number

113701-56-7

Storage

-20 °C or below

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