1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-ethanolamine (16:0 LPE) is a form of lysophosphatidylethanolamine (LPE), a minor lipid found in low levels in plasma membranes and serum which is generated through PLA2. LPE has been shown to increase intracellular Ca2+, invasiveness, and migration in SKOV3 and MDA-MB-231 cells. In addition, LPE accelerates ripening and increase the shelf-life of some fruits and vegetables such as tomatoes, grapes, and cranberries. Lysophospholipids are lipid mediators which elicit a diverse array of cellular responses through activation of phospholipid specific G protein-coupled receptors.
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1). K. Makide, et al “Novel lysophosphoplipid receptors: their structure and function” Journal of Lipid Research, 2014, 55, 1986-1995.
2) K.S. Park, et al, ” Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-rotein coupled receptor..” FEBS Lett., 2007, 581, 4411-4416.
Keywords: 16:0 LPE, 16:0 Lyso-PE