1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-ethanolamine (16:0 LPE) is a form of lysophosphatidylethanolamine (LPE), a minor lipid found in low levels in plasma membranes and serum which is generated through PLA2. LPE has been shown to increase intracellular Ca2+, invasiveness, and migration in SKOV3 and MDA-MB-231 cells. In addition, LPE accelerates ripening and increase the shelf-life of some fruits and vegetables such as tomatoes, grapes, and cranberries. Lysophospholipids are lipid mediators which elicit a diverse array of cellular responses through activation of phospholipid specific G protein-coupled receptors.
| Categories | Lipids |
|---|---|
| Filter | Lysophospholipid, Phosphatidylethanolamine |
| CAS Number | 53862-35-4 |
| Molecular Formula | C21H43NNaO7P |
| Molecular Weight (g/mol) | 453.55 |
| Purity | 95% |
| Storage | -20 °C or below |
1) K. Makide, et al “Novel lysophosphoplipid receptors: their structure and function” Journal of Lipid Research, 2014, 55, 1986-1995.
2) K.S. Park, et al, “Lysophosphatidylethanolamine stimulates chemotactic migration and cellular invasion in SK-OV3 human ovarian cancer cells: involvement of pertussis toxin-sensitive G-rotein coupled receptor.” FEBS Lett., 2007, 581, 4411-4416.
