Biotin Phosphatidylinositol is a water soluble analog of Phosphatidylinositol (PI) labeled with biotin at the sn-1 position.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.
Featured in Publications
1) Bidlingmaier, S., Y. Wang, et al. (2011). “Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions.” Mol Cell Proteomics 10(3): M110 005116.
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