7-Dehydrocholesterol (7-DHC) is an endogenous sterol that serves as a precursor to both cholesterol, through the enzyme 7-dehydrocholesterol reductase (DHCR7), and vitamin D3 by exposure to UVB radiation. Mutations in the DHCR7 gene can lead to the genetic disorder Smith-Lemli-Opitz Syndrome (SLOS). Substituting sterols for cholesterol in lipid nanoparticle (LNP) formulations can influence morphology, internal structure, and endosomal escape. These analogs can result in substantial increases in gene delivery via LNPs.
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7-Dehydrocholesterol (7-DHC)
7-Dehydrocholesterol (7-DHC) is an endogenous sterol that serves as a precursor to both cholesterol, through the enzyme 7-dehydrocholesterol reductase (DHCR7), and vitamin D3 by exposure to UVB radiation. [Read More...]
