AS604850 (PI3-K gamma Inhibitor 2)

Product Number: B-0302

$27.00$95.00

$27.00
$95.00

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-Kγ with an IC50 = 250 nM. AS604850 is selective for the γ-isoform (IC50: PI 3-Kα = 4.5 μM, PI 3-Kβ, PI 3-Kδ > 20 μM) and shows no notable activity against a wide array of protein kinases at 1 μM.

References

1) M. Camps et al. “Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis” Nature Medicine, 2005, 11, 936-943.


Categories

Biochemical Reagents

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Inhibitor, PI3K

CAS Number

648449-76-7

Molecular Formula

C11H7F2NO4S

Molecular Weight (g/mol)

287.2

Purity

95%

Storage

4 °C or below

Technical Data Sheet

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