AS604850 (PI3-K gamma Inhibitor 2)

Product Number: B-0302

Support

5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione (AS604850) is an inhibitor of PI 3-Kγ with an IC₅₀ = 250 nM. AS604850 is selective for the γ-isoform (IC₅₀: PI 3-Kα = 4.5 μM, PI 3-Kβ, PI 3-Kδ > 20 μM) and shows no notable activity against a wide array of protein kinases at 1 μM.

References

1) M. Camps et al. “Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis” Nature Medicine, 2005, 11, 936-943.

Categories	Biochemical Reagents
Filter	Inhibitor, PI3K
CAS Number	648449-76-7
Molecular Formula	C11H7F2NO4S
Molecular Weight (g/mol)	287.2
Purity	95%
Storage	4 °C or below