CAS Number: 673202-67-0
Molecular Weight: 953.63
Salt Form: TFA
Sequence (3-letter): D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2
Sequence (1-letter): rrrrrr-NH2
Storage: -20 °C or below
Solubility: 20% acetonitrile/water 1 mg/mL
Furin inhibitor II (Hexa-D-Arginine), as the name implies, inhibits furin (Ki = 106 nM for purified furin). Furin is an enzyme belonging to the subtilisin-like proprotein convertase family which process precursor proteins into biologically active products.
Representative substrates include von Willebrand factor, TGFβ-1 precursor, MMP-1, gp160, proparathyroid hormone and proalbumin. Peptide contains all D-amino acids; also called Hexa-D-Arg or Hexa-D-Arginine or (D-Arg)6-NH2
Results from a recent paper and preprint show the presence of a furin cleavage site on the spike protein of the SARS-CoV-2 which is required for membrane fusion and replication. Inhibition of furin activity can stop viral replication.
1. Cameron, A. et al. (2000) “Polyarginines Are Potent Furin Inhibitors” J. Biol. Chem. 275: 36741-36749.
2. Henrich, S. et al. (2005) “Proprotein Convertase Models based on the Crystal Structures of Furin and Kexin: Explanation of their Specificity” J. Mol. Biol. 345 (2): 211–227.