AS1938909 is a potent SHIP2 inhibitor (Ki = 0.44uM). This compound shows signficant selectivity over some related phosphatases (IC50 = 0.18uM, 21uM, >50uM for mSHIP2, hSHIP2, hPTEN respectively). It also enhances Akt phosphorylation and increases glucose consumption and uptake in L6 myotubes.
AS1938909 (SHIP2 Inhibitor)
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Kits & Assays
5′ PtdIns(3,4,5)P3 Phosphatase Activity Fluorescence Polarization Assay
Product Number: K-1400