CAP2

Product No: N-1912

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$600

Lipid Nanoparticles (LNPs) made from Cholesterol-Amino-Phosphate (CAP) CAP2 can deliver traditional mRNA and self-amplifying RNA (saRNA) encoding DNA Meiotic Recombinase 1 (Dmc1) protein in spermatocytes. A single injection of CAP2 LNPs–saRNA can produce Dmc1 protein for an extended period and restore spermatid production in the Dmc1 gene knockout mouse model.

Categories

Lipids

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Ionizable/Cationic Lipids

Molecular Formula

C59H102NO4P

Molecular Weight (g/mol)

920.44

Purity

>95%

Storage

-20 °C or below

Shipping Temp

Ambient Temperature

Technical Data Sheet

Du S. et al. “Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice” Adv. Sci. 2023, 2300188.
DOI: 10.1002/advs.202300188

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