BODIPY FL PI(3,4,5)P3

Product Number: C-39F6

$344.00$602.00

$344.00
$602.00

BODIPY FL PI(3,4,5)P3 (BODIPY FL Phosphatidylinositol 3,4,5-trisphosphate) is a water soluble analog of PI(3,4,5)P3 (PIP3) labeled with the green fluorophore, Bodipy®-FL at the sn-1 position.


Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Publications

1. Oganesian, A., M. Poot, et al. (2003). “Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.” Proc Natl Acad Sci U S A 100(13): 7563-8.
2. Rowe, T., et al. (2006). “A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.” Assay Drug Dev Technol 4(2): 175-183.
3. Caromile, L. A., A. Oganesian, et al. (2010). “The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.” J Biol Chem 285(14): 10487-96.
4. Jiang, D., et al. (2011). “Single-cell analysis of phosphoinositide 3-kinase and phosphatase and tensin homolog activation.” Faraday Discuss 149: 187-200
5. Lin, A., et al. (2017). “The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.” Nat Cell Biol 19(3): 238-251.

Bulk discounts available, please email echelon@echelon-inc.com for information.


Categories

Lipids

Filter

Fluorescent, Phosphoinositides, PI(3,4,5)P3

CAS Number

911205-85-1

Excitation/Emission

503/513 nm

Molecular Formula

C79H165BF2N10O23P4

Molecular Weight (g/mol)

1,795.91

Purity

>95%

Storage

-20 °C or below, protect from light

Technical Data Sheet

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