BODIPY FL PI(3,4,5)P3

Product Number: C-39F6

$361.00$632.00

$361.00
$632.00

BODIPY FL PI(3,4,5)P3 (BODIPY FL Phosphatidylinositol 3,4,5-trisphosphate) is a water soluble analog of PI(3,4,5)P3 (PIP3) labeled with the green fluorophore, Bodipy®-FL at the sn-1 position.


Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.

Bulk discounts available, please email echelon@echelon-inc.com for information.


Categories

Lipids

Filter

Fluorescent, Phosphoinositides, PI(3,4,5)P3

CAS Number

911205-85-1

Excitation/Emission

503/513 nm

Molecular Formula

C79H165BF2N10O23P4

Molecular Weight (g/mol)

1,795.91

Purity

>95%

Storage

-20 °C or below, protect from light

Technical Data Sheet

1. Oganesian, A., M. Poot, et al. (2003). “Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.” Proc Natl Acad Sci U S A 100(13): 7563-8.
2. Rowe, T., et al. (2006). “A high-throughput microfluidic assay for SH2 domain-containing inositol 5-phosphatase 2.” Assay Drug Dev Technol 4(2): 175-183.
3. Caromile, L. A., A. Oganesian, et al. (2010). “The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion.” J Biol Chem 285(14): 10487-96.
4. Jiang, D., et al. (2011). “Single-cell analysis of phosphoinositide 3-kinase and phosphatase and tensin homolog activation.” Faraday Discuss 149: 187-200
5. Lin, A., et al. (2017). “The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.” Nat Cell Biol 19(3): 238-251.

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