Biotin PI(3,4,5)P3 (Biotin Phosphatidylinositol 3,4,5-trisphosphate) is a water soluble analog of PI(3,4,5)P2 (PIP3) labeled with biotin at the sn-1 position.
Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3,4,5-trisphosphate (PIP3), formed from PI(4,5)P2 though phosphorylation by PI 3-kinase, activates numerous signaling pathways resulting in cell proliferation, growth, survival, glucose transport and protein synthesis. High PIP3 levels from disregulation of PI3-K have been demonstrated in cancer and inflammatory diseases. PIP3 is hydrolyzed by the phosphatases PTEN to PI(4,5)P2 and SHIP to PI(3,4)P2.
Featured in Publications
1. Anzelon, A. N., H. Wu, et al. (2003). “Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.” Nat Immunol 4(3): 287-94.
2. Bidlingmaier, S., et al. (2011). “Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions.” Mol Cell Proteomics 10(3): M110 005116.
3. Liu, J., et al. (2011). “Structural basis of phosphoinositide binding to Kindlin-2 pleckstrin homology domain in regulating integrin activation.” J Biol Chem 286(50): 43334-43342.
4. Lin, A., et al. (2017). “The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.” Nat Cell Biol 19(3): 238-251.
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