AS605240 (PI3-K gamma Inhibitor 1)

Product Number: B-0301

$29.00$66.00

$29.00
$66.00

5-quinoxilin-6-methylene-1,3-thiazolidine-2,4-dione (AS605240) is an ATP-competitive inhibitor of PI3-Kγ (IC50 = 8 nM). It is selective for the γ-isoform (IC50: PI 3-Kα = 60 nM, PI 3-Kβ = 270 nM, PI 3-Kδ = 300 nM) and shows no notable activity against a wide array of protein kinases at 1 μM. In addition, AS605240 suppresses the progression of joint inflammation in a mouse model of rheumatoid arthritis and suppresses inflammation in a mouse model of lupus.

References

1) M. Camps et al. “Blockade of PI3Kg suppresses joint inflammation and damage in mouse models of rheumatoid arthritis” Nature Medicine, 2005, 11, 936-943.
2) D.F. Barber, et al., “PI3Kg inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus” Nature Medicine, 2005, 11, 933-935.


Categories

Biochemical Reagents

Filter

Inhibitor, PI3K

CAS Number

648450-29-7

Molecular Formula

C12H7N3O2S

Molecular Weight (g/mol)

257.3

Purity

>95%

Storage

4 °C or below

Technical Data Sheet

You may also like…

  • PI-103 (PI3-K alpha Inhibitor 1) - Echelon Biosciences
    Biochemical Reagents

    PI-103 (PI3-K alpha Inhibitor 1)

    Product Number: B-0303

    $30.00$123.00 View products
  • PI3-K alpha Inhibitor 2 (3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol) - Echelon Biosciences
    Biochemical Reagents

    PI3-K alpha Inhibitor 2

    Product Number: B-0304

    $53.00$223.00 View products
  • PI3-Kinase Activity ELISA: Pico - Echelon Biosciences
    Kits & Assays

    PI3-Kinase Activity ELISA: Pico

    Product Number: K-1000S

    $345.00 View products
  • Phosphatidylinositol 4,5-bisphosphate diC8 (PI(4,5)P2 diC8) - Echelon Biosciences
    Lipids

    PI(4,5)P2 diC8

    Product Number: P-4508

    $44.00$358.00 View products
Shopping Cart
Scroll to Top