Apilimod (PIKfyve inhibitor)

Product Number: B-0308

$54.00$173.00

$54.00
$87.00
$173.00
SKU: B-0308 Category:

Background

Apilimod inhibits the kinase PIKfyve which phosphorylates PI(3)P to PI(3,5)P2 with an IC50 = 14 nM. PIKfyve has an important role in endosome formation and related pathways. Apilimod also inhibits Interleukin-12 (IL-12) and Interleukin-23 (IL-23) at 1-2 nM levels in cells. Apilimod has recently been shown to inhibit SARS-Cov2 replication in iPSC-derived pneumocyte-like cells and a primary human lung explant model. Apilimod is orally bioavailable and cell-permeable.

References

1) Y. Wada, et al. “Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor” Blood, (2007) 109(3), 1156-1164 doi: 10.1182/blood-2006-04-019398.
2) S. Gayle, et al. “Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma” (2017) 129 (13): 1768–1778. DOI: 10.1182/blood-2016-09-736892.
3) L. Riva et al. “ Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing” Nature (2020) https://doi.org/10.1038/s41586-020-2577-1

Filter

Inhibitor, Kinase

Categories

Biochemical Reagents

CAS Number

541550-19-0

Molecular Formula

C23H26N6O2

Molecular Weight (g/mol)

418.49

Purity

>98%

Storage

-20 °C or below

Technical Data Sheet

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