Apilimod (PIKfyve inhibitor)

Product Number: B-0308

$51.00$165.00

$51.00
$83.00
$165.00
SKU: B-0308 Category:

Background

Apilimod inhibits the kinase PIKfyve which phosphorylates PI(3)P to PI(3,5)P2 with an IC50 = 14 nM. PIKfyve has an important role in endosome formation and related pathways. Apilimod also inhibits Interleukin-12 (IL-12) and Interleukin-23 (IL-23) at 1-2 nM levels in cells. Apilimod has recently been shown to inhibit SARS-Cov2 replication in iPSC-derived pneumocyte-like cells and a primary human lung explant model. Apilimod is orally bioavailable and cell-permeable.

References

1) Y. Wada, et al. “Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor” Blood, (2007) 109(3), 1156-1164 doi: 10.1182/blood-2006-04-019398.
2) S. Gayle, et al. “Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma” (2017) 129 (13): 1768–1778. DOI: 10.1182/blood-2016-09-736892.
3) L. Riva et al. “ Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing” Nature (2020) https://doi.org/10.1038/s41586-020-2577-1

Technical Data Sheet

We are currently moving all Documentation links to this Tab we appreciate your patience. Please feel free to contact us if you have any questions or concerns.

Filter

Inhibitor, Kinase

Categories

Biochemical Reagents

Scroll to Top