CAS Number: 729589-58-6
Molecular Weight: 777.49
Salt Form: TFA
Sequence (3-letter): 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2
Sequence (1-letter): (2-Furoyl)LIGRL(Orn)-NH2
Storage: -20 °C or below
2-Furoyl-LIGRLO-NH2 is a potent and selective agonist of protease-activated receptor 2 (PAR2). 2-Furoyl-LIGRLO-NH2 caused both an endothelium-dependent relaxation and an endothelium-independent contraction in a rat model. It was more potent than SLIGRL-NH2 in producing delayed (6 hours) facilitation of capsaicin-evoked visceral nociception.
Reference: McGuire, JJ. et al. J Pharmacol Exp Ther (2004) 309, 1124 .