2-Furoyl-LIGRLO-NH2 (Potent and Selective Protease-Activated Receptor 2 (PAR2) Agonist)

Product Number: 873-10


SKU: 873-10 Category: Tag:

CAS Number: 729589-58-6
Molecular Weight: 777.49
Salt Form: TFA
Purity: >95%
Sequence (3-letter): 2-Furoyl-Leu-Ile-Gly-Arg-Leu-Orn-NH2
Sequence (1-letter): (2-Furoyl)LIGRL(Orn)-NH2
Storage: -20 °C or below

2-Furoyl-LIGRLO-NH2 is a potent and selective agonist of protease-activated receptor 2 (PAR2). 2-Furoyl-LIGRLO-NH2 caused both an endothelium-dependent relaxation and an endothelium-independent contraction in a rat model. It was more potent than SLIGRL-NH2 in producing delayed (6 hours) facilitation of capsaicin-evoked visceral nociception.

Reference: McGuire, JJ. et al. J Pharmacol Exp Ther (2004) 309, 1124 .

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