SH2-Domain containing inositol 5-phosphatases (SHIP1 & SHIP2) dephosphorylate the 5-position of PI(3,4,5)P3 generating PI(3,4)P2. SHIP2 is ubiquitously expressed while SHIP1 is found in hematolymphoid cells and mesancymal stem cells. K118 is a water soluble SHIP1 inhibitor which does not inhibit SHIP2. Treatment with K118 (10 mg/kg) on obese mice on a high fat diet resulted in reduced body mass and lowered fat content when compared to pre-treatment and non-treated control animals. The treated mice had reduced blood glucose and insulin levels in addition to improved glucose tolerance. K118 treatment also reduced the amount of age-related fat accumulation in mice.
| Categories | Biochemical Reagents |
|---|---|
| Filter | Inhibitor, SHIP |
| CAS Number | 54156-23-9 |
| Molecular Formula | C19H34ClN |
| Molecular Weight (g/mol) | 311.93 |
| Purity | >95% |
| Storage | 4 °C or below |
1) R, Brooks, et al. “Coordinate Expansion of Murine Hematopoietic and Mesenchymal Stem Cell Compartments by SHIPi”, Stem Cells, 2015, 33, 848-858. doi:10.1002/stem.1902
2) N. Srivastava “A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome” JCI Insight, 2016, 1, e88544 doi:10.1172/jci.insight.88544
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