2-Furoyl-LIGRL-Amide (Protease-Activated Receptor 2 (PAR2) Agonist)

Product Number: 873-11

$76.00

$76.00
SKU: 873-11 Category: Tag:

Molecular Weight: 663.41
Salt Form: TFA
Purity: >95%
Sequence (3-letter): 2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH2
Sequence (1-letter): (2-Furoyl)LIGRL-NH2
Storage: -20 °C or below

2-Furoyl-LIGRL-NH2 is a potent agonist of Protease-Activated Receptor 2 (PAR2). Treatment of mice with 2-Furoyl-LIGRL-NH2 resulted in gastric mucosal cytoprotective activity, the potency being much greater than SLIGRL-NH2 in combination with amastatin. Capsaicin pretreatment inhibited the cytoprotective activity. 2-Furoyl-LIGRL-NH2 treatment also prevented gastric mucosal lesions in mice.

Reference: Br J Pharmacol. 2005 Jan; 144(2): 212–219.

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