Molecular Weight: 663.41
Salt Form: TFA
Sequence (3-letter): 2-Furoyl-Leu-Ile-Gly-Arg-Leu-NH2
Sequence (1-letter): (2-Furoyl)LIGRL-NH2
Storage: -20 °C or below
2-Furoyl-LIGRL-NH2 is a potent agonist of Protease-Activated Receptor 2 (PAR2). Treatment of mice with 2-Furoyl-LIGRL-NH2 resulted in gastric mucosal cytoprotective activity, the potency being much greater than SLIGRL-NH2 in combination with amastatin. Capsaicin pretreatment inhibited the cytoprotective activity. 2-Furoyl-LIGRL-NH2 treatment also prevented gastric mucosal lesions in mice.
Reference: Br J Pharmacol. 2005 Jan; 144(2): 212–219.