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LIPID NANOPARTICLE
Resources
Accelerate your LNP formulation with us
Echelon’s Lipid Nanoparticle Services include mRNA synthesis, LNP formulation, and expression screening in cell culture. Utilize our combined expertise in cell biology and lipid chemistry to help select ionizable lipids to optimize LNPs with your cargo. All LNP lipid components are guaranteed in-stock to minimize turnaround time for your final LNP product.
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LNP Components
BUILDING BLOCKS OF LIPID NANOPARTICLES
A typical LNP includes an ionizable or cationic lipid, cholesterol, at least one phospholipid, and a polyethylene glycol (PEG) modified lipid. These lipid components are used to shield or encapsulate a nucleic acid cargo that encodes a therapeutic protein. The type of cargo ranges from mRNA or siRNA to plasmid DNA and the choice of lipids in the formulation is influenced by the cargo type. The primary concern here is the choice of the ionizable lipid. See our ionizable lipid selection guide below for more information.
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Ionizable Lipids
The key component to buildinga fully functional lnp
These specialized lipids obtain a positive charge in acidic pH, which allows them to interact with and encapsulate nucleic acids which contain negative charges via their phosphate groups. Screening and selection of ionizable lipids is based on the type of nucleic acid cargo, the target tissue, and therapeutic application.
View All Ionizable LipidsIonizable lipids selection guide
Not sure which ionizable lipid is best for your project? We can help! Check out our selection guide below or contact us anytime.
Target
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
1-A-N |
N-1001 |
siRNA/sgRNA |
Liver, Spleen |
|
Lipid A6 |
N-1006 |
mRNA |
Liver |
|
Lipid 5 |
N-1005 |
mRNA |
Liver |
|
LP-01 |
N-1007 |
siRNA/sgRNA |
Liver |
|
306Oi10 |
N-1010 |
mRNA |
Liver, Spleen |
|
cKK-E12 |
N-1012 |
mRNA, siRNA |
Liver |
|
CL4H6 |
N-1016 |
siRNA, sgRNA, protein |
Liver |
|
ALC-0315 |
N-1020 |
mRNA, siRNS, pDNA |
Liver |
|
OF-02 |
N-1022 |
mRNA |
Liver |
|
304O13 |
N-1029 |
siRNA |
Liver |
|
YSK05 |
N-1050 |
siRNA |
Liver |
|
SM-102 |
N-1102 |
mRNA |
Liver |
|
11-A-M |
N-1111 |
siRNA/sgRNA |
Spleen, Liver |
|
TT3 |
N-1113 |
mRNA |
Liver, spleen |
|
FTT5 |
N-1115 |
mRNA |
Liver |
|
306-O12B |
N-1128 |
mRNA, sgRNA |
Liver |
|
C12-200 |
N-1220 |
mRNA, siRNA, saRNA |
Liver, spleen |
|
DLin-MC3-DMA |
N-1282 |
siRNA, mRNA, pDNA |
Liver, spleen |
|
PPZ-A10 |
N-1410 |
mRNA |
Liver |
|
4A3-SC8 |
N-1438 |
mRNA |
Liver |
|
9A1P9 |
N-1919 |
mRNA, sgRNA |
Liver, Spleen |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
1-A-N |
N-1001 |
siRNA/sgRNA |
Spleen, liver |
|
306Oi10 |
N-1010 |
mRNA |
Liver, spleen |
|
CL4H6 |
N-1016 |
siRNA, sgRNA, protein |
Liver, spleen |
|
11-A-M |
N-1111 |
siRNA/sgRNA |
Spleen, liver |
|
TT3 |
N-1113 |
mRNA |
Liver, spleen |
|
93-O17O |
N-1170 |
mRNA, sgRNA |
Spleen, lymphocytes |
|
C12-200 |
N-1220 |
mRNA, siRNA, saRNA |
Liver, spleen |
|
DLin-MC3-DMA |
N-1282 |
siRNA, mRNA, pDNA |
Liver, spleen |
|
DLin-MC3-DMA |
N-1282 |
siRNA, mRNA, pDNA |
Liver, spleen |
|
9A1P9 |
N-1919 |
mRNA, sgRNA |
Liver, Spleen |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
Lipid OA2 |
N-1002 |
siRNA |
Tumor |
|
93-O17S |
N-1175 |
mRNA, sgRNA |
Lymphocytes, tumors |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
NT1-O14B |
N-1014 |
ASO, mRNA |
Brain |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
244cis |
N-1023 |
mRNA |
Lung |
|
4-O10b1 |
N-1114 |
siRNA |
Lung (intranasal) |
|
306-N16B |
N-1316 |
mRNA |
Lung |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
Lipid 10 |
N-1110 |
siRNA |
Leukocytes |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
93-O17O |
N-1170 |
mRNA, sgRNA |
Spleen, lymphocytes |
|
93-O17S |
N-1175 |
mRNA, sgRNA |
Lymphocytes, tumors |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
CAP2 |
N-1912 |
mRNA, saRNA |
Spermatocytes (microinjection) |
Cargo
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
1-A-N |
N-1001 |
siRNA/sgRNA |
Spleen, liver |
|
Lipid OA2 |
N-1002 |
siRNA |
Tumor |
|
LP-01 |
N-1007 |
siRNA/sgRNA |
Liver |
|
YHS-12 |
N-1009 |
mRNA, siRNA |
|
|
cKK-E12 |
N-1012 |
mRNA, siRNA |
Liver |
|
CL4H6 |
N-1016 |
siRNA, sgRNA, protein |
Liver, spleen |
|
ALC-0315 |
N-1020 |
mRNA, siRNA, pDNA |
Liver |
|
304O13 |
N-1029 |
siRNA |
Liver |
|
YSK05 |
N-1050 |
siRNA |
Liver |
|
ATX-0126 (ATX100) |
N-1100 |
siRNA |
|
|
Lipid 10 |
N-1110 |
siRNA |
Leukocytes |
|
11-A-M |
N-1111 |
siRNA/sgRNA |
Spleen, liver |
|
4-O10b1 |
N-1114 |
siRNA |
Lung (intranasal) |
|
C12-200 |
N-1220 |
mRNA, siRNA, saRNA |
Liver, spleen |
|
DLin-MC3-DMA |
N-1282 |
siRNA, mRNA, pDNA |
Liver, spleen |
|
Lipid 319 |
N-1319 |
siRNA |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
1-A-N |
N-1001 |
siRNA/sgRNA |
Spleen, liver |
|
LP-01 |
N-1007 |
siRNA/sgRNA |
Liver |
|
CL4H6 |
N-1016 |
siRNA, sgRNA, protein |
Liver, spleen |
|
11-A-M |
N-1111 |
siRNA/sgRNA |
Spleen, liver |
|
306-O12B |
N-1128 |
mRNA, sgRNA |
Liver |
|
93-O17O |
N-1170 |
mRNA, sgRNA |
Spleen, lymphocytes |
|
93-O17S |
N-1175 |
mRNA |
Lymphocytes, tumors |
|
OC2-K3-E10 |
N-1210 |
mRNA, sgRNA |
|
|
9A1P9 |
N-1919 |
mRNA, sgRNA |
Liver, Spleen |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
AA3-DLin |
N-1003 |
mRNA |
|
|
Lipid 5 |
N-1005 |
mRNA |
Liver |
|
Lipid A6 |
N-1006 |
mRNA |
Liver |
|
YHS-12 |
N-1009 |
mRNA, siRNA |
|
|
306Oi10 |
N-1010 |
mRNA |
Liver, spleen |
|
cKK-E12 |
N-1012 |
mRNA, siRNA |
Liver |
|
NT1-O14B |
N-1014 |
ASO, mRNA |
Brain |
|
DOG-IM4 |
N-1017 |
mRNA |
|
|
ALC-0315 |
N-1020 |
mRNA, siRNA, pDNA |
Liver |
|
OF-02 |
N-1022 |
mRNA |
Liver |
|
244cis |
N-1023 |
mRNA |
Lung |
|
Lipid C24 |
N-1024 |
mRNA |
|
|
C12-113 |
N-1027 |
mRNA |
|
|
SM-102 |
N-1102 |
mRNA |
Liver |
|
Lipid M |
N-1103 |
mRNA |
|
|
TT3 |
N-1113 |
mRNA |
Liver, spleen |
|
FTT5 |
N-1115 |
mRNA |
Liver |
|
306-O12B |
N-1128 |
mRNA, sgRNA |
Liver |
|
93-O17O |
N-1170 |
mRNA, sgRNA |
Spleen, lymphocytes |
|
93-O17S |
N-1175 |
mRNA, sgRNA |
Lymphocytes, tumors |
|
OC2-K3-E10 |
N-1210 |
mRNA, sgRNA |
|
|
C12-200 |
N-1220 |
mRNA, siRNA, saRNA |
Liver, spleen |
|
DLin-MC3-DMA |
N-1282 |
siRNA, mRNA, pDNA |
Liver, spleen |
|
306-N16B |
N-1316 |
mRNA |
Lung |
|
PPZ-A10 |
N-1410 |
mRNA |
Liver |
|
4A3-SC8 |
N-1438 |
mRNA |
Liver |
|
CAP2 |
N-1912 |
mRNA, saRNA |
Spermatocytes (microinjection) |
|
9A1P9 |
N-1919 |
mRNA, sgRNA |
Liver, Spleen |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
NT1-O14B |
N-1014 |
ASO, mRNA |
Brain |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
CL4H6 |
N-1016 |
siRNA, sgRNA, protein |
Liver, spleen |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
ALC-0315 |
N-1020 |
mRNA, siRNA, pDNA |
Liver |
|
DLin-MC3-DMA |
N-1282 |
siRNA, mRNA, pDNA |
Liver, spleen |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
80-O18 |
N-1118 |
Protein |
| Product Name | Catalog No. | Cargo | Targets |
|---|---|---|---|
|
C12-200 |
N-1220 |
mRNA, siRNA, saRNA |
Liver, spleen |
|
CAP2 |
N-1912 |
mRNA, saRNA |
Spermatocytes (microinjection) |
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Trusted By Scientists
"Echelon provided quality mRNA manufacturing and LNP formulation allowing for efficiency testing of our chimeric antigen receptors in primary human cells. Echelon’s scientists are professional and possess effective client communication."
"Echelon stood out for their ability to quickly generate and analyze a novel LNP formulation."
** the views represented are not official ones of the University or any of its units or officers
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LNP TRAILBLAZER KITS
SIMPLIFY LNP EXPLORATION
LNP Trailblazer Kits (K-6300L) are designed for quick assembly and assessment of RNA-LNPs in biological systems. Each kit includes a buffer for preparation of RNA cargo and the necessary lipids to form lipid nanoparticles. Once formed, RNA-LNPs are stable in neutral pH buffers for several weeks allowing them to be used serially for repeat experiments. The kit components are compatible with bench top microfluidic mixers and hand mixing by pipette. A kit with pre-mixed lipids in solution is also available (K-6300M).
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LIPID NANOPARTICLE
Catalog
DRIVING THE NEXT WAVE OF THERAPEUTIC INNOVATION
Lipid nanoparticles (LNPs) are now central to delivering nucleic acid–based
therapies—and their importance is only growing. As research expands into RNA-based
treatments and precision delivery systems, LNPs are proving essential for overcoming
biological barriers and enabling next-generation medicines.
Echelon Biosciences has been at the forefront of lipid science for over 27 years.
Our 2025 LNP Catalog offers the tools and knowledge to support every step of your discovery process.
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Get in Touch
If you have any questions or would like to learn more about our products or services, please reach out. We’re here to help!
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