…here to help you move your project forward with our high quality lipids. Phospholipids Phosphatidic Acid (PA) – Phosphatidylcholine (PC) – Phosphatidylethanolamine (PE) – Phosphatidylglycerol (PG) – Phosphatidylserine (PS) Phospholipids…
Phospholipidosis (PL) is lysosomal storage disorder characterized by the excessive accumulation of intracellular phospholipids (Figure 1). The mechanism of phospholipidosis is still unclear today, but it is known that phospholipidosis…
Phospholipid Enzymes in Cancer Phospholipids were once thought to be pedestrian structural components of cell membranes. Researchers have since discovered that specialized lipids (including phosphorylated inositol lipids, phosphoinositides, PIPs) are…
…which cleaves phospholipids to produce lysophospholipids and free fatty acids. The PLA2 family of enzymes is known to be at least 10 distinct members. sPLA2-V and sPLA2-X are selectively expressed…
…you in terms of both fixed price and FTE approaches. Our chemistry experience include: Complex lipids, phospholipids, and sphingolipids Small-molecule heterocycles Natural product semi-synthesis Peptides Synthesis of stable isotope labeled…
…the cytosol where their cargo can be delivered. Nanoparticle Composition LNPs are typically composed of four types of lipids: ionizable lipid, PEGylated lipid, cholesterol, and neutral phospholipids. The PEGylated lipids…
…promoting membrane fusion and promoting endosomal escape. Neutral phospholipids: Synthetic phospholipids (~10%) are also commonly used as structural “helper” lipids in LNP formulation to promote cell binding. Technical Notes Dried…
…efficacy possibly by promoting membrane fusion and promoting endosomal escape. Neutral phospholipid. Synthetic phospholipids such as DSPC, DPPC, and DOPE [~10%] are also commonly used as structural “helper” lipids in…
Z-PETH reacts primarily with phosphatidylethanol (of synthetic or natural origin), and demonstrates low cross-reactivity with other lipids and phospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidic acid, phosphatidylserine, phosphatidylglycerol, sphingomyelin, and cholesterol. The…
…excessive accumulation of intracellular phospholipids, causing tissue inflammation and organ damage. PL can manifest in patients taking certain cationic amphiphilic drugs (CADs) such as fluoxetine (Prozac™, Sarafem) and Amiodarone. The…