Zn (II) Deuteroporphyrin IX 2,4 bisethylene glycol

Product Number: F-H090

$252.00

$252.00
SKU: F-H090- Category: Tags: ,

Zn (II) Deuteroporphyrin IX 2,4 bis ethyleneglycol is an inhibitor of heme oxygenase (the enzyme that catalyzes the conversion of heme to biliverdin in the heme degradation pathway) at concentrations as low at 0.5 μM. Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair.

References

1) Chernick, R. J., P. Martasek, et al. (1989). “Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin.” Hepatology 10(3): 365-9.
2) Jozkowicz, A., H. Was, et al. (2007). “Heme oxygenase-1 in tumors: is it a false friend?” Antioxid Redox Signal 9(12): 2099-117.
3) Abraham, N. G. and A. Kappas (2005). “Heme oxygenase and the cardiovascular-renal system.” Free Radic Biol Med 39(1): 1-25.
4) Kim, D. H., A. P. Burgess, et al. (2008). “Heme oxygenase-mediated increases in adiponectin decrease fat content and inflammatory cytokines tumor necrosis factor-alpha and interleukin-6 in Zucker rats and reduce adipogenesis in human mesenchymal stem cells.” J Pharmacol Exp Ther 325(3): 833-40.

Categories

Biochemical Reagents

Filter

HEME Pathway, Porphyrin

CAS Number

15442-64-5

Molecular Formula

C34H36N4O8Zn

Molecular Weight (g/mol)

694.01

Purity

>95%

Storage

-20 °C or below, protect from light

Technical Data Sheet

You may also like…

Shopping Cart
Scroll to Top