Z-Phe-Arg-AFC (Cathepsin L Substrate)

Product Number: 866-75


SKU: 866-75 Category: Tag:

CAS Number: 65147-22-0
Molecular Weight: 666.24
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Z-Phe-Arg-AFC
Sequence (1-letter): Z-FR-AFC
Storage: -20 °C or below

Z-Phe-Arg-AFC is a fluorogenic for Cathepsin L. Cathepsin L is a lysosomal cysteine protease with an important role in initiating protein degradation. Cathepsin L is also upregulated in several cancers and has been suggested as a drug target. In addition,  extracellular secretion of Cathepsin L by tumors implicates it as a potential serum biomarker for  cancer progression.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.

We are in the process of migrating our technical data sheets (TDS) to this space. They can currently be found in the description section of the product pages. Thank you for your patience. For any technical questions, please contact us at echelon@echelon-inc.com





Enzyme Substrates

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