Z-Phe-Arg-AFC (Cathepsin L Substrate)

Product Number: 866-75


CAS Number: 65147-22-0
Molecular Weight: 666.24
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Z-Phe-Arg-AFC
Sequence (1-letter): Z-FR-AFC
Storage: -20 °C or below

Z-Phe-Arg-AFC is a fluorogenic for Cathepsin L. Cathepsin L is a lysosomal cysteine protease with an important role in initiating protein degradation. Cathepsin L is also upregulated in several cancers and has been suggested as a drug target. In addition,  extracellular secretion of Cathepsin L by tumors implicates it as a potential serum biomarker for  cancer progression.

Activity is quantified by release of free fluorescent 7-amino-4-trifluoromethylcoumarin (AFC) which excites at 395-400 nm and emits at 495-505 nm.




Enzyme Substrates

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Ambient Temperature


-20 °C or below

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