Z-Leu-Arg-AMC (Cathepsin, Kallikrein, Falcipain II substrate, fluorogenic)

CAS Number: 156192-32-4
Molecular Weight: 578.67
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Z-Leu-Arg-AMC
Sequence (1-letter): Z-LR-AMC
Storage: -20 °C or below

Z-Leu-Arg-AMC is a fluorogenic substrate for Cathepsins (K, L, V, S), and Kallikrein. It will also act as a substrate for Falcipains I-III but is the preferred substrate for Falcipain II. Falcipain II is a cysteine protease from Plasmodium falciparum which degrades hemoglobin and is a potential anti-malarial drug target.

Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.