Renin Substrate I

Product Number: 131-20


SKU: 131-20 Category: Tags: ,

CAS Number: 76524-84-0
Molecular Weight: 1299.66
Salt Form: TFA
Purity: >96%
Sequence (3-letter): Suc-Arg-Pro-Phe-His-Leu-Leu-Val-Tyr-AMC
Sequence (1-letter): Suc-RPFHLLVY-AMC
Storage: -20 °C or below

Renin Substrate I is a fluorogenic substrate for Renin which controls vasoconstriction and blood pressure as part of the Renin-angiotensin system (RAS). This peptide also acts as a substrate for the chymotrypsin-like activity of the 20S proteasome.
Activity is quantified by release of free fluorescent 7-amino-4-methylcoumarin (AMC) which excites at 360-380 nm and emits at 440-460 nm.


  1. K. Murakami, T. Ohsawa, S. Hirose, K. Takada, and S. Sakakibara, Anal. Biochem., 110, 232 (1981).
  2. H. Yokosawa, H. Ito, S. Murata, and S. Ishii, Anal. Biochem., 134, 210 (1983).

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Cardiovascular, Enzyme Substrates

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